Pig | CellWiki

Pig

Additional information

This page describes the morphology of an animal and is particularly intended for an insight into another world. The findings are based on only a few observations from residual material from animal experiments and have been assessed from a human diagnostic perspective. The differentiation algorithms of the human Sysmex XN equipment are not suitable for animal material. Students or professionals in veterinary medicine are advised to consult other sources of information for diagnostic purposes.

The white and red blood count of a pig is reminiscent of that of a patient with hemoglobinopathy and myelodysplasia. The substantial lymphocytosis of

9.5⋅10⁹/L

is reminiscent of a chronic lymphatic malignancy.

XN Scatterplots

wdf

wnr

pltf

ret

SFL

SSC

Lymphocytes

Monocytes

Neutrophils

Eosinophils

Basophils

Leukocytes

Basophils

NRBCs

Debris

Erythrocytes

Reticulocytes

RBC fragments

Platelets

immature platelets

Lymphocytes

Monocytes

Granulocytes

Reference

Focus

The WDF channel shows a clear dominance of the lymphocytic population , probably involving misclassification of lymphocytes as monocytes . The population of neutrophilic granulocytes is flattened and shifted to the left, which may indicate hypogranulation and/or aberrant nuclear segmentation . Only reduced erythrocyte size is observed in the RET tract .

Peripheral blood

The peripheral blood contained overtly small, abnormal erythrocytes; particularly echinocytes. Hemoglobin was

6.2 mmol/L

and MCV was

54 fL

which in humans may well fit iron deficiency or a hemoglobinopathy. The large amount of echinocytes is an artifact; the cell membrane contains relatively more cholesterol and has a different distribution of various phospholipids (especially saturated fatty acids) compared to humans. This different composition makes the erythrocyte of a pig a lot more sensitive to dehydration artifacts and effects of EDTA.

Neutrophils

The neutrophils, as the WDF channel suggested, are hypogranular. The nuclear segmentation is a lot less defined than usual in humans. For a pig this is perfectly normal; in a human this may fit with myelodysplasia.

Lymphocytes

The lymphocytes show strong similarity to those of humans. However, the lymphocyte count is high at 60% within a total leukocyte count of

16⋅10⁹/L

Monocytes

The monocytes are remarkably small compared to human monocytes. However, pig monocytes do exhibit similar blue-pink cytoplasm with some fine granules.

Basophils

This basophil appears to show some hyposegmentation. However, only one basophilic granulocyte was present making this an incidental finding.

Eosinophils

The eosinophilic granulocytes are very similar to those of humans.